The estimated risk of developing breast cancer on a background of reception of hormonal contraceptives

The use of modern hormonal contraceptives is associated with an increased risk of developing breast cancer (BC), and the risk increases with increasing duration of use. These are a study by Danish scientists published in the journal the New England Journal of Medicine.

The researchers analyzed the relationship between use of hormonal contraception and the risk of invasive breast cancer through a nationwide prospective cohort study involving 1.8 million Danish women 15 to 49 years without a history of cancer, venous thromboembolism and have not undergone fertility treatment.

For 10.9 years average follow-up period breast cancer was diagnosed in 11 of 517 participants. The results showed that the relative risk of cancer among women who use and who used hormonal contraception, made up 1.20. The risk depended on the duration of reception of contraceptives. For example, when using drugs for less than one year the relative risk of breast cancer was 1.09, an increase to 1.38 in ten years, the use of drugs. It is noted that the increased likelihood of developing cancer on a background of reception of hormonal contraception persisted for five years after cessation of therapy.

Risk indicators associated with taking combined oral contraceptives (estrogen-progestin), ranged from 1.0 to 1.6. Women who only used progesterone intrauterine contraceptives also had an increased risk of breast cancer (relative risk amounted to 1.21). In General, the overall absolute increase in rates of diagnosed breast cancer among women taking hormonal contraceptive drugs, was 13 per 100 thousand person-years or about 1 extra case of breast cancer among every 7690 women using hormonal contraception within one year.

However, the authors emphasize that the absolute risk increase was small. According to them, the risk of obesity due to prolonged use of hormonal contraceptives is even higher than the probability of breast cancer, so there is no need to abandon contraception.

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