The main factor of increasing life expectancy was a mutation affecting the metabolism of insulin in the body.
In 2009, scientists at the University of Kiel (Germany) reported that the life expectancy of a person depends on the gene FOXO3. But only now it became known, what mutations in this gene contribute to longevity. Details about the study reported in the journal Nature Communications.
Scientists from the Institute of clinical molecular biology discovered that two specific gene variant FOXO3 are more common in people who have lived 100 years, compared to those whose life expectancy ranged from 60 to 75 years. The study analyzed the DNA of the inhabitants of Germany, Denmark and France.
Life expectancy depends on many genetic factors. However, the gene FOXO3 plays an important role in insulin metabolism. It depends on the body’s response to nutritional stress: starvation, excess food. Experimental data showed that the detected genetic variance is to bring a person in modern conditions more harm than good. However, several thousand years ago, people with such genes was much more. Their share decreased due to drastic changes in the diet, with the result that these mutations are stopped to provide benefits.