The drug destroys the structure of the cell membrane of the pathogen and makes it more vulnerable.
In the fight against infectious diseases has entered a new era: scientists are developing brand-new methods to combat pathogens in order to avoid the possible appearance of drug resistance. In this spirit sustained development of scientists from Germany, which makes the causative agent of tuberculosis is a Mycobacterium is more vulnerable to the effects of any medicine.
A major problem in the fight against tuberculosis is a high density of their cell membranes, which reduces the effectiveness of drugs. A group of scientists led by Professor Stephan Sieberand from the Technical University of Munich (Germany) has discovered a substance which seriously disrupts the structure of the membrane.
An important structural element of the membrane of mycobacteria mycolic acids are. A similar structure has beta-lactones. The researchers used beta-lactone EZ120, which, thanks to its perfect affinity, violates the biosynthesis of micromembrane, blocking the enzyme Pks13 and Ag85, and effectively destroys bacteria.
EZ120 has been in small concentrations, showing low toxicity against human cells. Combination with antibiotics allows to considerably strengthen its effectiveness. When this synergy allows a reduction in the concentration of the drug more than 100 times.