Scientists from Stanford University, USA, have learned how to slow down age-related changes in the Central nervous system of people – it turned out that is needed to inhibit the activity of a specific protein. The researchers came to this decision when he noticed that blood transfusions from young mice to old animals in the experimental rodents were developing premature brain aging.
During the experiment, young mice were administered the plasma of older animals. It turned out that in these conditions, the hippocampus is activated synthesis of a specific protein (VCAM1), suppressing the formation of new nerve cells. It was also noted that in connection with such activity of the protein occurred inflammatory reaction involving immune cells of the Central nervous system.
In turn, biologists have formulated the inverse pattern. They came to the conclusion that blocking VCAM1 protein will help to slow down brain aging.
Indeed, according to the experiment, in cases when the mice were given antibodies that inhibited the activity of this protein, a blood transfusion from old animals had no significant negative effect on the hippocampus. According to the researchers, these antibodies could “stop neurodegeneration”.
The hippocampus is a brain region that is important for learning and memory formation. It is considered the most vulnerable area of the brain in the development of neurodegenerative diseases.