Sulfonamides and nitrofurantoin are still assigned to women with urinary tract infections (UTI) in the early stages of pregnancy. This is stated in the report of the Centers for control and disease prevention in USA (CDC).
Because of the potential risk of congenital malformation of the fetus, the experts of the American College of obstetricians and gynecologists (ACOG) in 2011 and opposed the appointment of sulfonamides and nitrofurantoin in the first trimester of pregnancy with the exception of cases in which antibiotics of a different type are clinically inappropriate.
The study of experts, CDC conducted an analysis of prescriptions for antibiotics to pregnant women with UTI in 2014. Overall data was carried 428 917 patients from 15 to 44 years.
The results showed that among pregnant women with UTI, antibiotics were prescribed in 68.9% of cases compared to 76.1% of women, the diagnosis of which was made within 90 days prior to the proposed last menstrual cycle.
The type of antibiotic prescription women diagnosed with the disease during or before pregnancy was different. In particular, fluoroquinolones and sulfonamides were often given to women before pregnancy (in any trimester), whereas nitrofurantoin, cephalosporins and penicillins during pregnancy.
The most common types of antibiotics prescribed to women in the first trimester of pregnancy, were: nitrofurantoin (34,7%), ciprofloxacin (10.5%) and cephalexin (10,3%) and trimethoprim/sulfamethoxazole (7.6 per cent). Thus, more than 4 out of 10 patients took antibiotics, not recommended for use during pregnancy.
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