German scientists were able to reveal important molecular mechanisms of development of age-related diseases.
Scientists from Jena centre of systems biology of aging (Germany) conducted a large-scale comparative study of aging in different animal species and tissue types. We compared changes in gene activity in various organs in humans, mice, fish zebrafish and ray-finned fishes. It turned out that the process of aging a lot in common, despite the differences in life expectancy of different creatures.
The scientists also compared the changes in gene activity with signs of age-related diseases. It was found that age related diseases are accompanied by the same changes, and degenerative diseases. Against open cancer the opposite pattern. That is, age does not necessarily contributes to age-related diseases in General, but has a special influence on the development of diseases. In this regard, especially in older ages the likelihood of cancer is reduced in comparison with degenerative diseases. Many genes increase the risk of degenerative diseases, protect the body from cancer and Vice versa.
In explanation of this, scientists have suggested that in the cells of aging people, the accumulation of damaged DNA. The immune system seeks to destroy damaged cells, to inhibit growth of the cancer. This may be the cause of slight chronic inflammation of many of the elderly, which contributes to degenerative tissue damage.