Why cells respond differently to stress?


Scientists from Germany have made considerable progress in studying the molecular processes that govern the response of cells to stressful situations.

Signs of stress is rapid heartbeat, increased blood pressure, etc. during the stress response, the blood is ejected “explosive mix” of hormones, which is then transported to the various tissues and cells. Thus, the stress subjected to the whole body. Reaction of different cells to stressful situations is different. For example, cells of adipose tissue to mobilize energy reserves, while the cells of the immune system inhibit its activity. The doctrine of the Institute of molecular genetics of them. Max Planck in Berlin decided to find out the nature of these differences.

It is known that physiological responses to stress are the result of changes in gene expression. In the experiment, the scientists deleted the genes from the genome-amps and checked reaction of the modified cells to stress. Thus identified several genes-enhancers that are responsible for stress-related changes of gene expression in specific cell types. It was found that during the stress response in bone cells responsible genes other than in the lung tissue. And bone cells during stress activates the DNA region located in the vicinity of the gene amplifier. In the cells of the lung gene-amplifier is located at a considerable distance from the respective plot. Scientists explain the differences in particular features a three-dimensional coagulation of the genome in the process of cell differentiation and education of their respective types.

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