Evaluated the relationship between varicose veins and the risk of developing deep vein thrombosis

Adult patients with varicose veins is five times more likely to develop deep vein thrombosis (DVT), according to a study published in the journal JAMA.

“Varicose veins are rarely associated with serious health risks. DVT, pulmonary embolism and peripheral artery disease (PAD), in contrast, constitutes disease, which are associated with serious systemic effects. Patients with varicose veins have elevated levels of inflammatory and prothrombotic markers,” explain the authors.

The researchers analyzed data from 212 984 patients suffering from varicose veins (mean age 54.5 years; 69,3% of women), and 212 984 randomly selected patients without varicose veins, DVT, peripheral arterial disease or embolism of pulmonary arteries (mean age of 54.3 years; 70.3 per cent).

With an average follow-up from 7.3 to 7.8 years, patients with varicose veins often suffer DVT than the control group (6,55 and 1.23 per 1000 person-years, respectively).

The incidence of embolism of the pulmonary arteries was also higher among patients with varicose veins (of 0.48 per 1000 person-years) compared with the control group (or 0.28 per 1000 person-years). Similarly, there was an increased risk of peripheral artery disease in the group of varicose veins, comprising of 10.73 per 1000 person-years vs of 6.22 in the control group. The results differed slightly depending on the gender and age of participants, the researchers noted.

Is there a relationship between varicose veins and DVT causal or represents a common set of risk factors, requires further research, said the scientists.

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