We investigated the relationship between postmenopausal bleeding and the risk of endometrial cancer

Almost all women with endometrial cancer have a history of postmenopausal bleeding (PMK), with only a small number of women with PMK will be diagnosed with endometrial cancer. These are the results of a study published in the journal JAMA Internal Medicine.

In the framework of the meta-analysis analyzed the results 129 studies involving 40 790 patients. A total of 34 432 patient had a history of PMK, 6358 participants were diagnosed with endometrial cancer.

Regardless of the stage of cancer at time of diagnosis the overall prevalence of PMK among women with endometrial cancer was 91%, the researchers reported. They also noted that this figure was higher among patients with endometrial cancer stage I, 94% of whom had a history of postmenopausal bleeding.

However, noted researchers, the risk of developing cancer was significantly lower among participants with MVP in history who took hormone therapy.

In accordance with current clinical guidelines, women with bleeding in postmenopausal women should undergo transvaginal ultrasound, endometrial biopsy and hysteroscopy with endometrial biopsy. The obtained results confirm the relevance of these recommendations and give confidence that a survey of women with PMK will reveal more cases of cancer at an early stage.

On the other hand, it was found that postmenopausal bleeding is associated with development of benign neoplasms and endometrial cancer will be diagnosed less than one woman with bleeding in postmenopausal women 10.

Since not all women with MVP will develop endometrial cancer, the risk should be properly communicated to patients, the researchers concluded.

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